Amiodarone Blue Man Syndrome
Amiodarone blue man syndrome. We present the case of a 77-year-old male who presented to us post-cardiac arrest secondary to hyperkalemia of 70. 4 This only occurs in about 13 of amiodarone users and is known as the blue man syndrome. The effect of amiodarone in the Wolff-Parkinson-White syndrome was studied with programmed electrical stimulation of the heart in 15 patients.
Images in cardiovascular medicine. J Am Acad Dermatol 1985. Programmed electrical stimulation was performed before and after 14 days of.
7 also had atrial fibrillation. The blue color ceruloderma is due to the deposition of melanin and lipofuscin contained in macrophages and endothelial cells in the dermis. Although photosensitivity reactions due to amiodarone are common bluish-grey skin discolouration is an uncommon adverse effect of amiodarone occurring in less than 3 of patients undergoing chronic therapy.
Both photosensitivity and less frequently phototoxicity are important dermatological side effects in particular because they may be cosmetically stigmatizing for the patients. Blue man syndrome is thought to stem from the deposition of lysosomal membrane-bound dense bodies similar to lipofuscin. Amiodarone is a common antiarrhythmic medication used in daily practice with excellent efficiency.
1 Cutaneous biopsy of discoloured skin has shown lysosomal membrane-bound dense bodies similar to lipofuscin. Conclusion Amiodarone-related hyperpigmentation should be considered a skin storage disease that is secondary to drug deposition. Turgay Yildirim Ö1 Turgay A2.
Your account has been temporarily locked due to incorrect sign in attempts and will be automatically unlocked in 30 mins. A much less common adverse reaction is the so-called Blue man syndrome occurring in 13 of patients. All 15 patients had circus movement tachycardias.
Low blood pressure. The pigmentation is reversible but it may take up to a year or more to complete resolution.
Alinovi A Reverberi C Melissari M Gabrielli M.
While it has many benefits there are several common adverse reactions such as abnormal thyroid function and cornea verticillata associated with its use. 2Department of Anesthesiology and Reanimation Sinop Atatürk State Hospital Sinop Turkey. Programmed electrical stimulation was performed before and after 14 days of. 1 Cutaneous biopsy of discoloured skin has shown lysosomal membrane-bound dense bodies similar to lipofuscin. 7 also had atrial fibrillation. Amiodarone toxicity is reviewed and summarized including pulmonary lung toxicity thyroid toxicity and hepatic liver toxicity. Alinovi A Reverberi C Melissari M Gabrielli M. Cutaneous hyperpigmentation induced by amiodarone hydrochloride. 2 Amiodarone may accelerate normal cellular autophagocytosis leading to.
These results demonstrate that amiodarone hyperpigmentation is related to drug deposition on photoexposed skin. J Am Acad Dermatol 1985. Amiodarone is a common antiarrhythmic medication used in daily practice with excellent efficiency. Commonly reported side effects of amiodarone include. Your account has been temporarily locked. Both photosensitivity and less frequently phototoxicity are important dermatological side effects in particular because they may be cosmetically stigmatizing for the patients. A type of inflammation of the lung called interstitial pneumonitis.
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